Neuropeptides and their receptors in the immune system

Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neu...

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Veröffentlicht in:	Annals of medicine (Helsinki) 1999-10, Vol.31, p.15-22
Hauptverfasser:	VAN HAGEN, P. M, HOFLAND, L. J, TEN BOKUM, A. M. C, LICHTENAUER-KALIGIS, E. G. R, KWEKKEBOOM, D. J, FERONE, D, LAMBERTS, S. W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune Diseases - drug therapy Biological and medical sciences General aspects Humans Immunopathology Leukocytes, Mononuclear - chemistry Leukocytes, Mononuclear - metabolism Medical sciences neuropeptide receptors neuropeptides Receptors, Neurokinin-1 - immunology Receptors, Somatostatin - immunology Somatostatin - analogs & derivatives Somatostatin - immunology Substance P - antagonists & inhibitors Substance P - immunology
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Beschreibung
Zusammenfassung:	Neuropeptides and their receptors are produced and expressed by neuroendocrine tissues and function as neurotransmitters and/or mediators of well-defined hormonal activities in specific tissues and cells. However, neuropeptides and their receptors are also found in the immune system, and various neuropeptides are involved in both systems. In this review we discuss the role of two of these neuropeptides, somatostatin and substance P, with regard to their receptor expression in the human immune system and their role in the diagnosis and treatment of immune-mediated diseases.
ISSN:	0785-3890 1365-2060