In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging
The in situ assessment of axonal projections of the brain has been severely limited by the lack of noninvasive techniques to study this type of anatomy. We show here that in vivo three‐dimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high‐resolution diffusion‐we...
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| Veröffentlicht in: | Magnetic resonance in medicine 1999-12, Vol.42 (6), p.1123-1127 |
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| container_title | Magnetic resonance in medicine |
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| creator | Xue, Rong van Zijl, Peter C.M. Crain, Barbara J. Solaiyappan, Meiyappan Mori, Susumu |
| description | The in situ assessment of axonal projections of the brain has been severely limited by the lack of noninvasive techniques to study this type of anatomy. We show here that in vivo three‐dimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high‐resolution diffusion‐weighted imaging technique combined with a recently designed fiber reconstruction algorithm. As a first example, neuronal pathways in the rat brain were probed. Eight well‐known fiber projections; genu and splenium of corpus callosum, internal and external capsule, fimbria, anterior commissure, optic tract, and stria terminalis were tracked and shown to be in agreement with the location of these known axonal projections. The experiment took 2 hr and shorter times should be possible in the clinical situation. By combining anisotropy information with fiber tracking, the anisotropy of individual projections was also documented. Magn Reson Med 42:1123–1127, 1999. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1522-2594(199912)42:6<1123::AID-MRM17>3.0.CO;2-H |
| format | Article |
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We show here that in vivo three‐dimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high‐resolution diffusion‐weighted imaging technique combined with a recently designed fiber reconstruction algorithm. As a first example, neuronal pathways in the rat brain were probed. Eight well‐known fiber projections; genu and splenium of corpus callosum, internal and external capsule, fimbria, anterior commissure, optic tract, and stria terminalis were tracked and shown to be in agreement with the location of these known axonal projections. The experiment took 2 hr and shorter times should be possible in the clinical situation. By combining anisotropy information with fiber tracking, the anisotropy of individual projections was also documented. Magn Reson Med 42:1123–1127, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/(SICI)1522-2594(199912)42:6<1123::AID-MRM17>3.0.CO;2-H</identifier><identifier>PMID: 10571934</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Axons ; Biological and medical sciences ; Brain - anatomy & histology ; diffusion tensor imaging ; Image Processing, Computer-Assisted - methods ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Medical sciences ; Nerve Fibers ; Nervous system ; neuronal connectivity study ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; rat ; Rats ; Rats, Sprague-Dawley ; Time Factors</subject><ispartof>Magnetic resonance in medicine, 1999-12, Vol.42 (6), p.1123-1127</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 1999 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5777-f982bad0a2cb4c89bd153c145c3953b979459039d83b6544fa46260615d4700e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291522-2594%28199912%2942%3A6%3C1123%3A%3AAID-MRM17%3E3.0.CO%3B2-H$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291522-2594%28199912%2942%3A6%3C1123%3A%3AAID-MRM17%3E3.0.CO%3B2-H$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1234352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10571934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xue, Rong</creatorcontrib><creatorcontrib>van Zijl, Peter C.M.</creatorcontrib><creatorcontrib>Crain, Barbara J.</creatorcontrib><creatorcontrib>Solaiyappan, Meiyappan</creatorcontrib><creatorcontrib>Mori, Susumu</creatorcontrib><title>In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The in situ assessment of axonal projections of the brain has been severely limited by the lack of noninvasive techniques to study this type of anatomy. We show here that in vivo three‐dimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high‐resolution diffusion‐weighted imaging technique combined with a recently designed fiber reconstruction algorithm. As a first example, neuronal pathways in the rat brain were probed. Eight well‐known fiber projections; genu and splenium of corpus callosum, internal and external capsule, fimbria, anterior commissure, optic tract, and stria terminalis were tracked and shown to be in agreement with the location of these known axonal projections. The experiment took 2 hr and shorter times should be possible in the clinical situation. By combining anisotropy information with fiber tracking, the anisotropy of individual projections was also documented. Magn Reson Med 42:1123–1127, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Axons</subject><subject>Biological and medical sciences</subject><subject>Brain - anatomy & histology</subject><subject>diffusion tensor imaging</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Nerve Fibers</subject><subject>Nervous system</subject><subject>neuronal connectivity study</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1v0zAYRiMEYmXwF5AvENouUvwZ1wVN2jpYizYq8bFO3LxyHGfzSJPNTsf673GaaiCBxJUl-_jo0UmSA4KHBGP6Zu_LbDLbJ4LSlArF94hSitB9TsfZO0IoG48PZ8fp2eczIg_YEA8n87c0nT5KBg9fHicDLDlOGVF8J3kWwjXGWCnJnyY7BAtJFOODpJjV6M7dNai98tamhVvaOrim1hXy1jR1aP3KtPECNSXyukW5165G-n6D3Pjm2m6eA8rXqHBluep-ozZaGo_cUl-6-vJ58qTUVbAvtudu8u3D-6-TaXo6P5lNDk9TI6SUaalGNNcF1tTk3IxUXhDBDOHCMCVYrqTiQmGmihHLM8F5qXlGM5wRUXCJsWW7yeveG3fdrmxoYemCsVWla9usAmSKqkjTCJ73oPFNCN6WcOPjVr8GgqHrD9D1hy4mdDGh7w-cQgZdf4DYHzb9gQGGyRwoTKP45XbBKl_a4g9tHzwCr7aADkZXpde1ceE3RyOzGbjosZ-usuu_1v1v3L-29RfRnPZmF1p7_2DW_gdkkkkBi08ncH70_WLx8eIIMPsFlUm9Pw</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Xue, Rong</creator><creator>van Zijl, Peter C.M.</creator><creator>Crain, Barbara J.</creator><creator>Solaiyappan, Meiyappan</creator><creator>Mori, Susumu</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging</title><author>Xue, Rong ; van Zijl, Peter C.M. ; Crain, Barbara J. ; Solaiyappan, Meiyappan ; Mori, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5777-f982bad0a2cb4c89bd153c145c3953b979459039d83b6544fa46260615d4700e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Axons</topic><topic>Biological and medical sciences</topic><topic>Brain - anatomy & histology</topic><topic>diffusion tensor imaging</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Nerve Fibers</topic><topic>Nervous system</topic><topic>neuronal connectivity study</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xue, Rong</creatorcontrib><creatorcontrib>van Zijl, Peter C.M.</creatorcontrib><creatorcontrib>Crain, Barbara J.</creatorcontrib><creatorcontrib>Solaiyappan, Meiyappan</creatorcontrib><creatorcontrib>Mori, Susumu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xue, Rong</au><au>van Zijl, Peter C.M.</au><au>Crain, Barbara J.</au><au>Solaiyappan, Meiyappan</au><au>Mori, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1999-12</date><risdate>1999</risdate><volume>42</volume><issue>6</issue><spage>1123</spage><epage>1127</epage><pages>1123-1127</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>The in situ assessment of axonal projections of the brain has been severely limited by the lack of noninvasive techniques to study this type of anatomy. We show here that in vivo three‐dimensional (3D) reconstruction of axonal projections can be achieved using a rapid 3D high‐resolution diffusion‐weighted imaging technique combined with a recently designed fiber reconstruction algorithm. As a first example, neuronal pathways in the rat brain were probed. Eight well‐known fiber projections; genu and splenium of corpus callosum, internal and external capsule, fimbria, anterior commissure, optic tract, and stria terminalis were tracked and shown to be in agreement with the location of these known axonal projections. 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| source | Wiley-Blackwell Journals; MEDLINE; Wiley Free Archive |
| subjects | Animals Axons Biological and medical sciences Brain - anatomy & histology diffusion tensor imaging Image Processing, Computer-Assisted - methods Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences Nerve Fibers Nervous system neuronal connectivity study Radiodiagnosis. Nmr imagery. Nmr spectrometry rat Rats Rats, Sprague-Dawley Time Factors |
| title | In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging |
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