A new approach to the synthesis of efaroxan

efaroxan was synthetised by cyclisation of the tertiary alcohol 2 which was prepared by the ring opening of the gem-disubstituted epoxide 3 with ortho-metallated fluorobenzene. [Display omitted]

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-10, Vol.9 (20), p.3023-3026
Hauptverfasser:	Couture, K., Gouverneur, V., Mioskowski, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - chemical synthesis Benzofurans - chemical synthesis Biological and medical sciences Catecholaminergic system Chemistry cyclisation dihydrobenzofurane efaroxan epoxide Epoxy Compounds - chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Imidazoles - chemical synthesis Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Organic chemistry Pharmacology. Drug treatments Preparations and properties
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	efaroxan was synthetised by cyclisation of the tertiary alcohol 2 which was prepared by the ring opening of the gem-disubstituted epoxide 3 with ortho-metallated fluorobenzene. [Display omitted]
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00530-2