Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors

Solid organ donors often develop hypotension due to vasodilation, and recently we observed that a variety of vasodilatory states are characterized by vasopressin deficiency and hypersensitivity. Thus, we investigated the prevalence of vasopressin deficiency in hypotensive solid organ donors without clinical evidence of diabetes insipidus; we also investigated the vasopressor effect of vasopressin replacement in hypotensive donors. Fifty organ donors were evaluated for hemodynamic instability, (mean arterial pressure [MAP]