Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems

A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particula...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-01, Vol.6 (14), p.2554-2559
Hauptverfasser:	Hurley, Christopher A, Wong, John B, Ho, Jimmy, Writer, Michele, Irvine, Scott A, Lawrence, M Jayne, Hart, Stephen L, Tabor, Alethea B, Hailes, Helen C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line DNA - metabolism Gene Transfer Techniques Genetic Vectors - metabolism Glycerol - analogs & derivatives Glycerol - chemistry Glycerol - metabolism Humans Lipid Metabolism Peptides - chemistry Peptides - metabolism Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Transfection
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Beschreibung
Zusammenfassung:	A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b719702k