Tea Catechin Supplementation Increases Antioxidant Capacity and Prevents Phospholipid Hydroperoxidation in Plasma of Humans

The effect of green tea catechin supplementation on antioxidant capacity of human plasma was investigated. Eighteen healthy male volunteers who orally ingested green tea extract (254 mg of total catechins/subject) showed 267 pmol of epigallocatechin-3-gallate (EGCg) per milliliter of plasma at 60 mi...

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Veröffentlicht in:	Journal of agricultural and food chemistry 1999-10, Vol.47 (10), p.3967-3973
Hauptverfasser:	Nakagawa, Kiyotaka, Ninomiya, Manabu, Okubo, Tsutomu, Aoi, Nobuyuki, Juneja, Lekh Raj, Kim, Mujo, Yamanaka, Kenji, Miyazawa, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antioxidants - pharmacology Biological and medical sciences blood lipids blood plasma Catechin - blood Catechin - pharmacology Chromatography, High Pressure Liquid Coffee, tea and other stimulative beverage industries Dietary Supplements epigallocatechin-3-gallate extracts flavanols Food industries Fundamental and applied biological sciences. Psychology General pharmacology Humans ingestion lipid peroxidation Male Medical sciences oral administration Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phosphatidylcholine hydroperoxide phosphatidylcholines Phosphatidylcholines - blood Plant Extracts - pharmacology Reference Values Tea Time Factors
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Zusammenfassung:	The effect of green tea catechin supplementation on antioxidant capacity of human plasma was investigated. Eighteen healthy male volunteers who orally ingested green tea extract (254 mg of total catechins/subject) showed 267 pmol of epigallocatechin-3-gallate (EGCg) per milliliter of plasma at 60 min after administration. The plasma phosphatidylcholine hydroperoxide (PCOOH) levels attenuated from 73.7 pmol/mL in the control to 44.6 pmol/mL in catechin-treated subjects, being correlated inversely with the increase in plasma EGCg level. The results suggested that drinking green tea contributes to prevent cardiovascular disease by increasing plasma antioxidant capacity in humans. Keywords: Tea catechin; antioxidant; lipid peroxidation; phosphatidylcholine hydroperoxide; human plasma
ISSN:	0021-8561 1520-5118
DOI:	10.1021/jf981195l