Changes in micturition after spinal cord injury in conscious rats

Objectives. To determine the feasibility of urodynamic monitoring of voiding function in conscious, female spinal cord-injured (SCI) rats and to compare the voiding function in SCI rats and those with normal spinal cord (NSC). Methods. Cystometrograms were performed on conscious, female Sprague-Dawl...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 1999-11, Vol.54 (5), p.929-933
Hauptverfasser:	Yoshiyama, Mitsuharu, Nezu, Frank M, Yokoyama, Osamu, de Groat, William C, Chancellor, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Consciousness Female Medical sciences Nephrology. Urinary tract diseases Rats Rats, Sprague-Dawley Spinal Cord Injuries - physiopathology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urination Urodynamics
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Zusammenfassung:	Objectives. To determine the feasibility of urodynamic monitoring of voiding function in conscious, female spinal cord-injured (SCI) rats and to compare the voiding function in SCI rats and those with normal spinal cord (NSC). Methods. Cystometrograms were performed on conscious, female Sprague-Dawley rats. Parameters measured included voided volume, residual volume, volume threshold for inducing micturition, voiding efficiency, micturition pressure, pressure threshold for inducing micturition, and bladder contraction duration. SCI animals were studied 2 to 3 weeks after T8-T10 spinal cord transection. Results. Approximately one half of SCI rats exhibited uninhibited bladder contractions before voiding. These contractions were not observed in NSC rats. Compared with NSC rats, SCI rats had larger volume thresholds (1.43 versus 0.34 mL, P
ISSN:	0090-4295 1527-9995
DOI:	10.1016/S0090-4295(99)00234-4