Malignant fibrous histiocytoma after allogeneic bone marrow transplantation

A 24-year-old woman with CML underwent allogeneic BMT in August 1995 from a one-antigen HLA mismatched brother. Conditioning included BuCy2 and CsA and MTX were used to prevent GVHD. In July 1997 she developed right leg pain, lytic bone lesions of distal femur and a solid mass of soft tissue. Histol...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 1999-11, Vol.24 (9), p.1029-1031
Hauptverfasser:	VELA-OJEDA, J, DIAZ DE LEON, L, TRIPP-VILLANUEVA, F, SANCHEZ-CORTES, E, AYALA-SANCHEZ, M, GARCIA-RUIZ ESPARZA, M, ROSAS-CABRAL, A, GONZALEZ-LLAVEN, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens Biological and medical sciences Bone lesions Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Bone marrow, stem cells transplantation. Graft versus host reaction Bone mass Chemotherapy Doxorubicin Female Femoral Neoplasms - diagnosis Femoral Neoplasms - etiology Femur Graft-versus-host reaction Histiocytoma Histiocytoma, Benign Fibrous - diagnosis Histiocytoma, Benign Fibrous - etiology Histocompatibility antigen HLA Humans Ifosfamide Leukemia, Myeloid, Chronic-Phase - therapy Male Medical sciences Metastases Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - etiology Pain Soft Tissue Neoplasms - diagnosis Soft Tissue Neoplasms - etiology Soft tissues Stem cell transplantation Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation, Homologous Tumors
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Zusammenfassung:	A 24-year-old woman with CML underwent allogeneic BMT in August 1995 from a one-antigen HLA mismatched brother. Conditioning included BuCy2 and CsA and MTX were used to prevent GVHD. In July 1997 she developed right leg pain, lytic bone lesions of distal femur and a solid mass of soft tissue. Histological diagnosis of malignant fibrous histiocytoma was made. Despite treatment with surgery and chemotherapy (doxorubicin and ifosfamide), the patient died 1 year later with local recurrence of the tumor and liver, lung and brain metastases. The CML was in CR.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1701919