Aplysamine 6, an Alkaloidal Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the Sponge Pseudoceratina sp

The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an α,β-unsaturated amide linkage, as the bioactiv...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-06, Vol.71 (6), p.1066-1067
Hauptverfasser:	Buchanan, Malcolm S, Carroll, Anthony R, Fechner, Gregory A, Boyle, Anthony, Simpson, Moana, Addepalli, Rama, Avery, Vicky M, Hooper, John N. A, Cheung, Tony, Chen, Huwei, Quinn, Ronald J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Australia Biological and medical sciences General pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Protein Methyltransferases - antagonists & inhibitors Tyrosine - analogs & derivatives Tyrosine - chemistry Tyrosine - isolation & purification Tyrosine - pharmacology
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Zusammenfassung:	The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an α,β-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0706623