Palladium-Catalyzed Chloroimination of Imidoyl Chlorides to a Triple Bond: An Intramolecular Reaction Leading to 4-Chloroquinolines

Palladium-Catalyzed Chloroimination of Imidoyl Chlorides to a Triple Bond: An Intramolecular Reaction Leading to 4-Chloroquinolines

In this paper, a new type of effective chloroimination was reported. This reaction afforded 4-chloro-2-perfluoroalkyl quinolines from fluorinated imidoyl chlorides in high yields. This is the first achievement of oxidative addition−reductive elimination type C−Cl bond activation by chloropalladation...

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Veröffentlicht in:Organic letters 2008-07, Vol.10 (13), p.2657-2659
Hauptverfasser: Isobe, Akira, Takagi, Jun, Katagiri, Toshimasa, Uneyama, Kenji
Format: Artikel
Sprache:eng
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Zusammenfassung:In this paper, a new type of effective chloroimination was reported. This reaction afforded 4-chloro-2-perfluoroalkyl quinolines from fluorinated imidoyl chlorides in high yields. This is the first achievement of oxidative addition−reductive elimination type C−Cl bond activation by chloropalladation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800512m