Total Synthesis of Polyoxygenated Cembrenes

Total Synthesis of Polyoxygenated Cembrenes

A convergent approach for the stereoselective construction of polyoxygenated cembrenes is reported. Key steps in the synthesis are an asymmetric domino multicomponent allylation, a modified Myers α‐alkylation, and a ring‐closing metathesis.

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-06, Vol.47 (28), p.5246-5249
Hauptverfasser: Tietze, Lutz F, Brazel, C. Christian, Hölsken, Sören, Magull, Jörg, Ringe, Arne
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
allylation
cembrenes
Cyclization
Diterpenes - chemical synthesis
Diterpenes - chemistry
epoxidation
metathesis
Oxygen - chemistry
terpenoids
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Zusammenfassung:A convergent approach for the stereoselective construction of polyoxygenated cembrenes is reported. Key steps in the synthesis are an asymmetric domino multicomponent allylation, a modified Myers α‐alkylation, and a ring‐closing metathesis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200800626