The combined detection of umbilical cord nucleated red blood cells and lactate: early prediction of neonatal hypoxic ischemic encephalopathy

Objective: To establish a simple and quick method that could be used to predict the occurrence of hypoxic ischemic encephalopathy (HIE) as early as possible by investigating the variations of nucleated red blood cells per 100 white blood cell (NRBC/100 WBC) counts and lactate levels in cord blood. M...

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Veröffentlicht in:	Journal of perinatal medicine 2008-01, Vol.36 (3), p.240-247
Hauptverfasser:	Haiju, Zhang, Suyuan, Hao, Xiufang, Fan, Lu, Yang, Sun, Ruopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers - blood Case-Control Studies Cord blood Delivery. Postpartum. Lactation Erythroblasts Erythrocyte Count Female Fetal Distress - blood Gynecology. Andrology. Obstetrics Humans Hypoxia-Ischemia, Brain - diagnosis hypoxic-ischemic-encephalopathy Infant, Newborn lactate Lactic Acid - blood Male Medical sciences nucleated red blood cell prediction Predictive Value of Tests ROC Curve Umbilical Cord - chemistry Umbilical Cord - cytology
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Zusammenfassung:	Objective: To establish a simple and quick method that could be used to predict the occurrence of hypoxic ischemic encephalopathy (HIE) as early as possible by investigating the variations of nucleated red blood cells per 100 white blood cell (NRBC/100 WBC) counts and lactate levels in cord blood. Methods: In 46 cases of acute fetal distress (AFD) and 54 cases of chronic fetal distress (CFD) neonates we measured the percentage (NRBCs/100 WBC) and lactate in the umbilical blood. Results: Both lactate levels and NRBC/100WBC counts were higher in CFD and AFD groups than in controls (both P
ISSN:	0300-5577 1619-3997
DOI:	10.1515/JPM.2008.035