Short-term Results of Penetrating Keratoplasty Performed with the Femtec Femtosecond Laser

Purpose To evaluate the use of the Femtec femtosecond (fs) laser for penetrating keratoplasty (PK) in the treatment of corneal diseases. Design Prospective, nonrandomized clinical study. Methods Nine eyes of nine patients underwent surgery for PK. Five had pseudophakic bullous keratopathy, three had Fuchs dystrophy, and one presented in a keratoconus patient. A Femtec (20/10 PerfectVision; GmbH, Heidelberg, Germany) fs laser was used to create penetrating cuts on donor and recipient corneas. All patients were evaluated for uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), pachymetry, topography, and endothelial cell density (ECD). Scanning electron microscopy (SEM) was performed on corneal tissue after surgery. Results All eyes were treated successfully without intraoperative complications. The mean follow-up was 6 ± 3 months. At the last postoperative examination mean BSCVA was 20/69 and there was a significant improvement ( P = .08) in both UCVA and BSCVA. Mean astigmatism was 2.9 ± 1.2 diopters. Mean ECD was 1194 ± 465 cells/mm2 with a mean cell loss after surgery of 49.8% ± 19.8%. SEM displayed smooth rectilinear cut margins and minor remaining tissue bridges. One patient presented a retinal detachment three months after surgery that was successfully treated and two subjects showed an allograft rejection. Conclusion Use of the Femtec fs laser was effective and safe to perform PK. Short-term visual results and refractive results are analogous to conventional PK or other fs laser–assisted PK studies. Longer-term follow-up of additional cases is necessary to precisely quantify the endothelial cell loss after fs surgery.