Conservation of structure among glycosylphosphatidylinositol toxins from different geographic isolates of Plasmodium falciparum
GPIs exhibit a variety of functions beyond their role as membrane anchors. They have been shown to be involved in the maturation and transport of membrane proteins, in signal transduction processes and as pathogenicity factors especially in falciparum malaria. GPIs of Plasmodium spp. have been shown...
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| Veröffentlicht in: | Molecular and biochemical parasitology 1999-10, Vol.103 (2), p.273-278 |
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| container_title | Molecular and biochemical parasitology |
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| creator | Berhe, Saba Schofield, Louis Schwarz, Ralph T. Gerold, Peter |
| description | GPIs exhibit a variety of functions beyond their role as membrane anchors. They have been shown to be involved in the maturation and transport of membrane proteins, in signal transduction processes and as pathogenicity factors especially in falciparum malaria. GPIs of Plasmodium spp. have been shown to be involved in the induction of the release of high levels of tumour necrosis factor alpha , interleukin 1 and nitric oxide from host macrophages. Therefore plasmodial GPIs are likely to be relevant for the development of pathology in severe and cerebral malaria and thus are a malaria toxin. |
| doi_str_mv | 10.1016/S0166-6851(99)00125-5 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0166-6851 |
| ispartof | Molecular and biochemical parasitology, 1999-10, Vol.103 (2), p.273-278 |
| issn | 0166-6851 1872-9428 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Carbohydrate Sequence Evolution, Molecular Geography Glycosylphosphatidylinositol Glycosylphosphatidylinositols - chemistry GPI Malaria, Falciparum - epidemiology Molecular Epidemiology Molecular Sequence Data Plasmodium Plasmodium falciparum Plasmodium falciparum - chemistry Plasmodium falciparum - classification Species Specificity Toxin Toxins, Biological - chemistry |
| title | Conservation of structure among glycosylphosphatidylinositol toxins from different geographic isolates of Plasmodium falciparum |
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