Conservation of structure among glycosylphosphatidylinositol toxins from different geographic isolates of Plasmodium falciparum

GPIs exhibit a variety of functions beyond their role as membrane anchors. They have been shown to be involved in the maturation and transport of membrane proteins, in signal transduction processes and as pathogenicity factors especially in falciparum malaria. GPIs of Plasmodium spp. have been shown...

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Veröffentlicht in:Molecular and biochemical parasitology 1999-10, Vol.103 (2), p.273-278
Hauptverfasser: Berhe, Saba, Schofield, Louis, Schwarz, Ralph T., Gerold, Peter
Format: Artikel
Sprache:eng
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Zusammenfassung:GPIs exhibit a variety of functions beyond their role as membrane anchors. They have been shown to be involved in the maturation and transport of membrane proteins, in signal transduction processes and as pathogenicity factors especially in falciparum malaria. GPIs of Plasmodium spp. have been shown to be involved in the induction of the release of high levels of tumour necrosis factor alpha , interleukin 1 and nitric oxide from host macrophages. Therefore plasmodial GPIs are likely to be relevant for the development of pathology in severe and cerebral malaria and thus are a malaria toxin.
ISSN:0166-6851
1872-9428
DOI:10.1016/S0166-6851(99)00125-5