Analysis of histopathological changes that influence liver stiffness in chronic hepatitis C. Results from a cohort of 324 patients

The current study aims to assess the role of the histological parameters in liver biopsy for explaining the variance of liver stiffness, as well as the performance of transient elastography in quantifying liver fibrosis in patients with chronic hepatitis C. 324 consecutive CHC patients were prospect...

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Veröffentlicht in:	Journal of gastrointestinal and liver diseases : JGLD 2008-06, Vol.17 (2), p.155-163
Hauptverfasser:	Lupşor, Monica, Badea, Radu, Stefănescu, Horia, Grigorescu, Mircea, Sparchez, Zeno, Serban, Alexandru, Branda, Horatiu, Iancu, Sorana, Maniu, Anca
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Disease Progression DNA, Viral - analysis Elasticity Elasticity Imaging Techniques Female Follow-Up Studies Hepacivirus - genetics Hepatitis C, Chronic - complications Hepatitis C, Chronic - pathology Hepatitis C, Chronic - physiopathology Humans Liver - pathology Liver - physiopathology Liver - virology Liver Cirrhosis - etiology Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology Male Middle Aged Prognosis Retrospective Studies ROC Curve
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Zusammenfassung:	The current study aims to assess the role of the histological parameters in liver biopsy for explaining the variance of liver stiffness, as well as the performance of transient elastography in quantifying liver fibrosis in patients with chronic hepatitis C. 324 consecutive CHC patients were prospectively included in this study. All of them had positive HCV-RNA in serum and had underwent percutaneous liver biopsy for grading and staging the diseases (METAVIR scoring system). All were referred to liver stiffness measurement 1 day prior to biopsy. Liver stiffness values were strongly correlated with fibrosis (r=0.759, p
ISSN:	1841-8724