In vitro activity of daptomycin against multidrug-resistant Staphylococcus aureus and S. aureus with known virulence factors, including community-acquired methicillin-resistant isolates

Abstract The in vitro activity of daptomycin was evaluated against 360 multidrug-resistant Staphylococcus aureus isolates (including hospital-acquired isolates) and multidrug-susceptible community-acquired methicillin-resistant S. aureus with known virulence genes. All isolates were inhibited at ≤1...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2008-07, Vol.61 (3), p.339-342
Hauptverfasser:	Anastasiou, Diane M, Morgan, Margie, Ruane, Peter J, Steenbergen, Judith N, Katz, Bradley D, Alder, Jeff D, Thorne, Grace M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacteriology Biological and medical sciences Community-Acquired Infections - microbiology Community-acquired methicillin-resistant Staphylococcus aureus Cross Infection - microbiology Daptomycin Daptomycin - pharmacology Drug Resistance, Multiple, Bacterial Fundamental and applied biological sciences. Psychology Humans Infectious Disease Infectious diseases Internal Medicine Medical sciences Methicillin Resistance Microbial Sensitivity Tests Microbiology Miscellaneous Multidrug-resistant Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - isolation & purification Virulence Factors - analysis
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Zusammenfassung:	Abstract The in vitro activity of daptomycin was evaluated against 360 multidrug-resistant Staphylococcus aureus isolates (including hospital-acquired isolates) and multidrug-susceptible community-acquired methicillin-resistant S. aureus with known virulence genes. All isolates were inhibited at ≤1 μg/mL, suggesting that daptomycin has excellent activity against both hospital-acquired and community-acquired S. aureus isolates.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2008.01.012