Pichindé virus is trafficked through a dynamin 2 endocytic pathway that is dependent on cellular Rab5- and Rab7-mediated endosomes

Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-depend...

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Veröffentlicht in:	Archives of virology 2008-07, Vol.153 (7), p.1391-1396
Hauptverfasser:	Vela, Eric M, Colpitts, Tonya M, Zhang, Lihong, Davey, Robert A, Aronson, Judith F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arenavirus Arenavirus - physiology Biological and medical sciences Biomedical and Life Sciences Biomedicine Brief Report Cercopithecus aethiops clathrin Dynamin II - metabolism endocytosis endosomes Endosomes - chemistry Endosomes - virology Fundamental and applied biological sciences. Psychology Gene expression Hydrogen-Ion Concentration Infections Infectious Diseases Medical Microbiology Microbiology Miscellaneous Pichinde virus rab GTP-Binding Proteins - analysis rab5 GTP-Binding Proteins - analysis Vero Cells Viral infections Virology Virus Internalization Viruses
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Beschreibung
Zusammenfassung:	Pichindé virus (PICV) is a New World arenavirus that has been shown to enter cells through a clathrin-dependent endocytic pathway. In this study, we determined that PICV is trafficked through the cellular dynamin 2 (dyn2) endocytic pathway. Additionally, the data suggest that PICV entry is pH-dependent and that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes. In all, this study characterizes the endocytic pathway utilized by the arenavirus PICV.
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-008-0129-3