In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma
Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 1999/10/15, Vol.22(10), pp.1147-1149 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1149 |
|---|---|
| container_issue | 10 |
| container_start_page | 1147 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 22 |
| creator | KIM, Na-Young KANG, Tai-Hyun PAE, Hyun-Ock CHOI, Byung-Min CHUNG, Hun-Taeg MYUNG, Seung-Woon SONG, Yun-Seon SHON, Dong-Hwan KIM, Youn-Chul |
| description | Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN-γ) plus lipopolysaccharide (LPS). The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting. |
| doi_str_mv | 10.1248/bpb.22.1147 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69232245</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3120429981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c634t-4b5da86da73511f6d75b88fdbdc746218414946bc4b9ff6c13e037374d5275d63</originalsourceid><addsrcrecordid>eNpd0MuLFDEQB-AgijuunrxLg-JFekzlneOyuDq4uODrGvJqJ0M_ZpNucP3rzTjDKl5ShPqoKn4IPQe8BsLUW7d3a0LWAEw-QCugTLacAH-IVliDagVwdYaelLLDGEtM6GN0BpgzraRYoY-bsfme5jw1mzEsPrk-Np_qP_nm5mcKsflyN87bWFKpYJtcmqdcmi5PQ3PRpzLYuXY-b9OvabBP0aPO9iU-O9Vz9O3q3dfLD-31zfvN5cV16wVlc8scD1aJYCXlAJ0IkjuluuCCl0wQUAyYZsJ55nTXCQ80YiqpZIETyYOg5-j1ce4-T7dLLLMZUvGx7-0Yp6UYoQklhPEKX_4Hd9OSx3qbAcZqOEQzWtWbo_J5KiXHzuxzGmy-M4DNIWFTEzaEmEPCVb84zVzcEMM_9hhpBa9OwBZv-y7b0afy14FWgpHKro5sV2b7I973bZ6T7-NhJ2hN_-zFp_dwwD3wW5tNHOlv1AiaIg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1449182943</pqid></control><display><type>article</type><title>In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Free Full-Text Journals in Chemistry</source><creator>KIM, Na-Young ; KANG, Tai-Hyun ; PAE, Hyun-Ock ; CHOI, Byung-Min ; CHUNG, Hun-Taeg ; MYUNG, Seung-Woon ; SONG, Yun-Seon ; SHON, Dong-Hwan ; KIM, Youn-Chul</creator><creatorcontrib>KIM, Na-Young ; KANG, Tai-Hyun ; PAE, Hyun-Ock ; CHOI, Byung-Min ; CHUNG, Hun-Taeg ; MYUNG, Seung-Woon ; SONG, Yun-Seon ; SHON, Dong-Hwan ; KIM, Youn-Chul</creatorcontrib><description>Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN-γ) plus lipopolysaccharide (LPS). The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.22.1147</identifier><identifier>PMID: 10549876</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Alismatis Rhizoma ; alismol ; alisol B monoacetate ; Animals ; Biological and medical sciences ; Cells, Cultured ; Cholestenones - isolation & purification ; Cholestenones - pharmacology ; Enzyme Inhibitors - isolation & purification ; Enzyme Inhibitors - pharmacology ; General pharmacology ; inducible nitric oxide synthase (iNOS) ; inhibitor ; Magnoliopsida - chemistry ; Medical sciences ; Mice ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitric Oxide Synthase - biosynthesis ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type II ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; RAW 264.7 cell ; RNA, Messenger - metabolism ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology</subject><ispartof>Biological and Pharmaceutical Bulletin, 1999/10/15, Vol.22(10), pp.1147-1149</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>2000 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c634t-4b5da86da73511f6d75b88fdbdc746218414946bc4b9ff6c13e037374d5275d63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1198642$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10549876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIM, Na-Young</creatorcontrib><creatorcontrib>KANG, Tai-Hyun</creatorcontrib><creatorcontrib>PAE, Hyun-Ock</creatorcontrib><creatorcontrib>CHOI, Byung-Min</creatorcontrib><creatorcontrib>CHUNG, Hun-Taeg</creatorcontrib><creatorcontrib>MYUNG, Seung-Woon</creatorcontrib><creatorcontrib>SONG, Yun-Seon</creatorcontrib><creatorcontrib>SHON, Dong-Hwan</creatorcontrib><creatorcontrib>KIM, Youn-Chul</creatorcontrib><title>In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN-γ) plus lipopolysaccharide (LPS). The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.</description><subject>Alismatis Rhizoma</subject><subject>alismol</subject><subject>alisol B monoacetate</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Cholestenones - isolation & purification</subject><subject>Cholestenones - pharmacology</subject><subject>Enzyme Inhibitors - isolation & purification</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>General pharmacology</subject><subject>inducible nitric oxide synthase (iNOS)</subject><subject>inhibitor</subject><subject>Magnoliopsida - chemistry</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - biosynthesis</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>RAW 264.7 cell</subject><subject>RNA, Messenger - metabolism</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0MuLFDEQB-AgijuunrxLg-JFekzlneOyuDq4uODrGvJqJ0M_ZpNucP3rzTjDKl5ShPqoKn4IPQe8BsLUW7d3a0LWAEw-QCugTLacAH-IVliDagVwdYaelLLDGEtM6GN0BpgzraRYoY-bsfme5jw1mzEsPrk-Np_qP_nm5mcKsflyN87bWFKpYJtcmqdcmi5PQ3PRpzLYuXY-b9OvabBP0aPO9iU-O9Vz9O3q3dfLD-31zfvN5cV16wVlc8scD1aJYCXlAJ0IkjuluuCCl0wQUAyYZsJ55nTXCQ80YiqpZIETyYOg5-j1ce4-T7dLLLMZUvGx7-0Yp6UYoQklhPEKX_4Hd9OSx3qbAcZqOEQzWtWbo_J5KiXHzuxzGmy-M4DNIWFTEzaEmEPCVb84zVzcEMM_9hhpBa9OwBZv-y7b0afy14FWgpHKro5sV2b7I973bZ6T7-NhJ2hN_-zFp_dwwD3wW5tNHOlv1AiaIg</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>KIM, Na-Young</creator><creator>KANG, Tai-Hyun</creator><creator>PAE, Hyun-Ock</creator><creator>CHOI, Byung-Min</creator><creator>CHUNG, Hun-Taeg</creator><creator>MYUNG, Seung-Woon</creator><creator>SONG, Yun-Seon</creator><creator>SHON, Dong-Hwan</creator><creator>KIM, Youn-Chul</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma</title><author>KIM, Na-Young ; KANG, Tai-Hyun ; PAE, Hyun-Ock ; CHOI, Byung-Min ; CHUNG, Hun-Taeg ; MYUNG, Seung-Woon ; SONG, Yun-Seon ; SHON, Dong-Hwan ; KIM, Youn-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c634t-4b5da86da73511f6d75b88fdbdc746218414946bc4b9ff6c13e037374d5275d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alismatis Rhizoma</topic><topic>alismol</topic><topic>alisol B monoacetate</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Cholestenones - isolation & purification</topic><topic>Cholestenones - pharmacology</topic><topic>Enzyme Inhibitors - isolation & purification</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>General pharmacology</topic><topic>inducible nitric oxide synthase (iNOS)</topic><topic>inhibitor</topic><topic>Magnoliopsida - chemistry</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - biosynthesis</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>RAW 264.7 cell</topic><topic>RNA, Messenger - metabolism</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIM, Na-Young</creatorcontrib><creatorcontrib>KANG, Tai-Hyun</creatorcontrib><creatorcontrib>PAE, Hyun-Ock</creatorcontrib><creatorcontrib>CHOI, Byung-Min</creatorcontrib><creatorcontrib>CHUNG, Hun-Taeg</creatorcontrib><creatorcontrib>MYUNG, Seung-Woon</creatorcontrib><creatorcontrib>SONG, Yun-Seon</creatorcontrib><creatorcontrib>SHON, Dong-Hwan</creatorcontrib><creatorcontrib>KIM, Youn-Chul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIM, Na-Young</au><au>KANG, Tai-Hyun</au><au>PAE, Hyun-Ock</au><au>CHOI, Byung-Min</au><au>CHUNG, Hun-Taeg</au><au>MYUNG, Seung-Woon</au><au>SONG, Yun-Seon</au><au>SHON, Dong-Hwan</au><au>KIM, Youn-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>22</volume><issue>10</issue><spage>1147</spage><epage>1149</epage><pages>1147-1149</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN-γ) plus lipopolysaccharide (LPS). The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>10549876</pmid><doi>10.1248/bpb.22.1147</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 1999/10/15, Vol.22(10), pp.1147-1149 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69232245 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Alismatis Rhizoma alismol alisol B monoacetate Animals Biological and medical sciences Cells, Cultured Cholestenones - isolation & purification Cholestenones - pharmacology Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology inducible nitric oxide synthase (iNOS) inhibitor Magnoliopsida - chemistry Medical sciences Mice Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments RAW 264.7 cell RNA, Messenger - metabolism Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology |
| title | In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T22%3A27%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Vitro%20Inducible%20Nitric%20Oxide%20Synthesis%20Inhibitors%20from%20Alismatis%20Rhizoma&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=KIM,%20Na-Young&rft.date=1999-10-01&rft.volume=22&rft.issue=10&rft.spage=1147&rft.epage=1149&rft.pages=1147-1149&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.22.1147&rft_dat=%3Cproquest_cross%3E3120429981%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1449182943&rft_id=info:pmid/10549876&rfr_iscdi=true |