In Vitro Inducible Nitric Oxide Synthesis Inhibitors from Alismatis Rhizoma

Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1999/10/15, Vol.22(10), pp.1147-1149
Hauptverfasser:	KIM, Na-Young, KANG, Tai-Hyun, PAE, Hyun-Ock, CHOI, Byung-Min, CHUNG, Hun-Taeg, MYUNG, Seung-Woon, SONG, Yun-Seon, SHON, Dong-Hwan, KIM, Youn-Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Alismatis Rhizoma alismol alisol B monoacetate Animals Biological and medical sciences Cells, Cultured Cholestenones - isolation & purification Cholestenones - pharmacology Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology inducible nitric oxide synthase (iNOS) inhibitor Magnoliopsida - chemistry Medical sciences Mice Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments RAW 264.7 cell RNA, Messenger - metabolism Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
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Zusammenfassung:	Bioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN-γ) plus lipopolysaccharide (LPS). The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.22.1147