Adult-onset angiofibroma and multiple endocrine neoplasia type I

Adult-onset angiofibroma and multiple endocrine neoplasia type I

Multiple endocrine neoplasia type 1 (MEN 1) predisposes affected persons to neoplasms of the parathyroid glands, the endocrine pancreas, the anterior pituitary, and the duodenum. We report the first case of adult-onset multiple angiofibromas of the central face associated with MEN 1. Seven siblings...

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Veröffentlicht in:Journal of the American Academy of Dermatology 1999-11, Vol.41 (5), p.890-892
Hauptverfasser: Hoang-Xuan, Tuan, Steger, James W.
Format: Artikel
Sprache:eng
Schlagworte:
Adenoma - complications
Adenoma - pathology
Adult
Angiofibroma - complications
Angiofibroma - pathology
Biological and medical sciences
Dermatology
Face
Humans
Male
Medical sciences
Multiple Endocrine Neoplasia Type 1 - complications
Paraneoplastic Syndromes - pathology
Pituitary Neoplasms - complications
Skin Neoplasms - complications
Skin Neoplasms - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:Multiple endocrine neoplasia type 1 (MEN 1) predisposes affected persons to neoplasms of the parathyroid glands, the endocrine pancreas, the anterior pituitary, and the duodenum. We report the first case of adult-onset multiple angiofibromas of the central face associated with MEN 1. Seven siblings also developed adult-onset angiofibromas, none with evidence of tuberous sclerosis. Basic fibroblast growth factor (BFGF) is elevated in many patients with MEN 1 and may play a pathogenetic role. (J Am Acad Dermatol 1999;41: 890-2.)
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(99)70353-1