Evaluation of Immune Memory of Human Lymphocytes Engrafted in SCID Mice

Evaluation of Immune Memory of Human Lymphocytes Engrafted in SCID Mice

Peripheral blood lymphocytes (PBL) isolated from 17 healthy subjects were engrafted i.p. each to an individual SCID mouse. After 48 hours the mice were tested for skin response to the common recall antigen PPD at various sites on the body periphery. In 8 of them PPD elicited a distinct positive skin...

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Veröffentlicht in:Immunobiology (1979) 1999-09, Vol.201 (1), p.145-150
Hauptverfasser: Peled, Alpha, Leykin, Igor, Deckmann, Michael, Shinitzky, Meir
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Animals
Female
Humans
Hypersensitivity, Delayed - immunology
Immunologic Memory - immunology
Lymphocyte Transfusion
Lymphocytes - immunology
Male
Mice
Mice, SCID
Middle Aged
Tuberculin - immunology
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Zusammenfassung:Peripheral blood lymphocytes (PBL) isolated from 17 healthy subjects were engrafted i.p. each to an individual SCID mouse. After 48 hours the mice were tested for skin response to the common recall antigen PPD at various sites on the body periphery. In 8 of them PPD elicited a distinct positive skin reaction only at the abdomen. This procedure could provide a basis for detection of specific cellular immune response such as in autoimmune diseases.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(99)80053-9