Effect of microdialysis perfusion of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol in the perifornical hypothalamus on sleep–wakefulness: Role of δ-subunit containing extrasynaptic GABAA receptors

Abstract Gaboxadol or 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridine-3-ol (THIP) is a selective agonist for the δ-subunit containing extrasynaptic GABAA receptors that will soon enter the U.S. market as a sleep aid [Winsky-Sommerer R, Vyazovskiy VV, Homanics GE, Tobler I (2007) The EEG effects of THIP...

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Veröffentlicht in:	Neuroscience 2008-05, Vol.153 (3), p.551-555
Hauptverfasser:	Thakkar, M.M, Winston, S, McCarley, R.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals GABA Agonists - administration & dosage Hypothalamus - drug effects Hypothalamus - metabolism Injections, Intraventricular Isoxazoles - administration & dosage Male Microdialysis Neurology Rats Rats, Sprague-Dawley Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Sleep - drug effects Wakefulness - drug effects
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