Three-dimensional sonographic measurement of contralateral lung volume in fetuses with isolated congenital diaphragmatic hernia

Purpose To use 3‐dimensional sonography (3DUS) to measure contralateral lung volume and evaluate the potential of this measurement to predict neonatal outcome in isolated congenital diaphragmatic hernia (CDH). Methods Between January 2002 and December 2004, the contralateral lung volumes of 39 fetuses with isolated CDH were measured via 3DUS using rotational multiplanar imaging. The observed/expected contralateral fetal lung volume ratios (o/e‐ContFLVR) were compared with the lung/head ratio (LHR), observed/expected total fetal lung volume ratio (o/e‐TotFLVR), and postnatal outcome. Results Contralateral lung volumes are less reduced than total lung volumes in CDH. The bias and precision of 3DUS in estimating contralateral lung volumes were 0.99 cm3 and 1.11 cm3, respectively, with absolute limits of agreement ranging from −1.19 cm3 to +3.17 cm3. The o/e‐ContFLVR was significantly lower in neonatal death cases (median, 0.49 cm3; range, 0.22–0.99 cm3) than in survival cases (median, 0.58 cm3; range, 0.42–0.92 cm3 [p < 0.01]). Overall accuracy of the o/e‐ContFLVR, o/e‐TotFLVR, and LHR in predicting neonatal death were 67.7% (21/31), 80.7% (25/31), and 77.4% (24/31), respectively. Conclusion Although o/e‐ContFLVR can be precisely measured with 3DUS and can be used to predict neonatal death in CDH, it is less accurate than LHR and o/e‐TotFLVR for that purpose. © 2007 Wiley Periodicals, Inc. J Clin Ultrasound, 2008