Synthesis, analysis and in vitro antibacterial activity of new metal complexes of sulbactam

Complexes of copper(II), nickel(II) and iron(III) with β-lactamase inhibitor sulbactam have been synthesized, characterized and identified by elemental analysis, IR and 1H NMR spectroscopy. These complexes have been then tested for their in vitro antibacterial activity in combination with ampicillin...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 1998-12, Vol.53 (12), p.737-740
Hauptverfasser:	Kostova, Irena P, Changov, Lubomir S, Keuleyan, Emma E, Gergova, Rayna T, Manolov, Ilia I
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin Ampicillin - pharmacology Anti-Bacterial Agents - analysis Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Copper Fungi - drug effects Iron Magnetic Resonance Spectroscopy Medical sciences Metal complexes of sulbactam Microbial Sensitivity Tests Nickel Pharmacology. Drug treatments Spectrophotometry, Infrared Sulbactam Sulbactam - analogs & derivatives Sulbactam - analysis Sulbactam - pharmacology β-Lactamase inhibitor
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Zusammenfassung:	Complexes of copper(II), nickel(II) and iron(III) with β-lactamase inhibitor sulbactam have been synthesized, characterized and identified by elemental analysis, IR and 1H NMR spectroscopy. These complexes have been then tested for their in vitro antibacterial activity in combination with ampicillin against various bacterial species.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/S0014-827X(98)00092-5