Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis

Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis

The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent r...

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Veröffentlicht in:FEMS immunology and medical microbiology 2008-06, Vol.53 (1), p.1-7
Hauptverfasser: Calich, Vera L.G, Pina, Adriana, Felonato, Maíra, Bernardino, Simone, Costa, Tania A, Loures, Flávio V
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Blastomycoses and paracoccidioidomycosis
Fundamental and applied biological sciences. Psychology
Fungal infections
fungal pathogens
Fungi
Human mycoses
Humans
Immune system
Immunity, Innate
Infectious diseases
Innate immunity
Medical sciences
Microbiology
Mycoses
MyD88
MyD88 protein
Myeloid Differentiation Factor 88 - immunology
Paracoccidioides - immunology
paracoccidioidomycosis
Paracoccidioidomycosis - immunology
Pathogenesis
pathogens
Pattern recognition
Pattern recognition receptors
Receptors
South American blastomycosis
TLR2
TLR2 protein
TLR4
TLR4 protein
Toll-Like Receptor 2 - immunology
Toll-Like Receptor 4 - immunology
Toll-like receptors
Tropical mycoses
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Beschreibung
Zusammenfassung:The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent results on the function of TLR4, TLR2 and the MyD88 adaptor molecule in the pathogenesis of paracoccidioidomycosis are presented.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.2008.00378.x