Chiral Phosphoric Acid Catalyzed Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes: Cooperative Effect of 3 Å Molecular Sieves

Chiral Phosphoric Acid Catalyzed Enantioselective Friedel-Crafts Alkylation of Indoles with Nitroalkenes: Cooperative Effect of 3 Å Molecular Sieves

Crafty catalysts: Friedel–Crafts alkylation of indoles with nitroalkenes proceeded in the presence of phosphoric acid 1 and 3 Å molecular sieves to give Friedel–Crafts adducts with excellent enantioselectivities (see scheme).

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2008-05, Vol.47 (21), p.4016-4018
Hauptverfasser: Itoh, Junji, Fuchibe, Kohei, Akiyama, Takahiko
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Alkylation
asymmetric synthesis
Brønsted acids
Catalysis
enantioselectivity
Friedel-Crafts alkylation
Hydrogen Bonding
indoles
Indoles - chemical synthesis
Indoles - chemistry
Molecular Structure
Nitro Compounds - chemistry
Phosphoric Acids - chemistry
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Crafty catalysts: Friedel–Crafts alkylation of indoles with nitroalkenes proceeded in the presence of phosphoric acid 1 and 3 Å molecular sieves to give Friedel–Crafts adducts with excellent enantioselectivities (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200800770