Benzyl Protection of Phenols under Neutral Conditions: Palladium-Catalyzed Benzylations of Phenols

Benzyl Protection of Phenols under Neutral Conditions: Palladium-Catalyzed Benzylations of Phenols

Benzyl protection of phenols under neutral conditions was achieved by using a Pd(η3-C3H5)Cp–DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of...

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Veröffentlicht in:Organic letters 2008-05, Vol.10 (10), p.1979-1982
Hauptverfasser: Kuwano, Ryoichi, Kusano, Hiroki
Format: Artikel
Sprache:eng
Schlagworte:
Benzene Derivatives - chemistry
Catalysis
Ethers - chemical synthesis
Ethers - chemistry
Ligands
Molecular Structure
Organometallic Compounds - chemistry
Palladium - chemistry
Phenols - chemistry
Stereoisomerism
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Zusammenfassung:Benzyl protection of phenols under neutral conditions was achieved by using a Pd(η3-C3H5)Cp–DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded in the presence of the catalyst, yielding aryl benzyl ethers.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol800548t