Sweet's syndrome associated with multiple myeloma

Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis. It may be paraneoplastic in 10 to 20% of cases. Association with multiple myeloma (MM) is uncommon. We report on a 73-year-old woman that developed SS 2 months after being diagnosed with IgG MM. Cutaneous lesions improved rapidly after chemotherapy for the MM. No recurrence of SS has taken place during the subsequent 2 years. Association of SS with MM has been rarely described in the literature. Only 14 cases of SS with MM have been reported. The secretory status of the MM may influence the occurrence of SS. SS seems to be related to IgG MM. Patients with IgG MM may have more risk of developing SS than those with other secretory types.