The direct role of vitamin D on bone homeostasis

Vitamin D requires two metabolic conversions, 25-hydroxylation in the liver and 1α-hydroxylation in the kidney, before its hormonal form, 1,25-dihydroxyvitamin D [1,25-(OH) 2D], can bind to the vitamin D receptor (VDR) to modulate gene transcription and regulate mineral ion homeostasis. The receptor...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2008-05, Vol.473 (2), p.225-230
1. Verfasser:	St-Arnaud, René
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25-Dihydroxyvitamin D 25-Hydroxyvitamin D-1-α-hydroxylase 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Animals Bone and Bones - physiology Calcium - physiology Cell Differentiation Chondrocytes Chondrocytes - cytology Chondrocytes - physiology Homeostasis Humans Osteoblasts - cytology Osteoblasts - physiology Osteogenesis Phosphates - metabolism RANK Ligand - metabolism Receptors, Calcitriol - metabolism Signal Transduction Vitamin D - analogs & derivatives Vitamin D - physiology Vitamin D receptor
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