Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT6 receptor ligands

The synthesis of new pharmaceutically interesting 3-(2-N,N-diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield. Further sulfonylation of these novel indoles g...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-05, Vol.6 (10), p.1802-1807
Hauptverfasser:	Alex, Karolin, Schwarz, Nicolle, Khedkar, Vivek, Sayyed, Iliyas Ali, Tillack, Annegret, Michalik, Dirk, Holenz, Jörg, Díaz, José Luis, Beller, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Chlorine Compounds - chemistry Ethyl Ethers - chemical synthesis Ethyl Ethers - chemistry Ethyl Ethers - metabolism Ethylamines - chemistry Indoles - chemical synthesis Indoles - chemistry Indoles - metabolism Ligands Molecular Structure Receptors, Serotonin - metabolism
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Zusammenfassung:	The synthesis of new pharmaceutically interesting 3-(2-N,N-diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield. Further sulfonylation of these novel indoles gave access to potential 5-HT(6) receptor ligands.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/b802054j