Caged Retinoic Acid for One- and Two-Photon Excitation in Zebrafish Embryos

Escaping the cage: Retinoic acid (RA), a crucial signaling molecule for the embryogenesis of vertebrates, can be photoreleased from a simple caged derivative (cRA) upon illumination. In zebrafish embryos, cRA causes RA‐induced phenotypes with one‐ and two‐photon excitation (see picture), which opens...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2008-05, Vol.47 (20), p.3744-3746
Hauptverfasser:	Neveu, Pierre, Aujard, Isabelle, Benbrahim, Chouaha, Le Saux, Thomas, Allemand, Jean-François, Vriz, Sophie, Bensimon, David, Jullien, Ludovic
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bioorganic chemistry cage compounds Embryo, Nonmammalian - metabolism embryogenesis Embryonic Development photolysis Photons retinoic acid Tretinoin - analogs & derivatives Tretinoin - analysis Tretinoin - chemistry Tretinoin - metabolism Zebrafish - embryology Zebrafish - metabolism
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Beschreibung
Zusammenfassung:	Escaping the cage: Retinoic acid (RA), a crucial signaling molecule for the embryogenesis of vertebrates, can be photoreleased from a simple caged derivative (cRA) upon illumination. In zebrafish embryos, cRA causes RA‐induced phenotypes with one‐ and two‐photon excitation (see picture), which opens a route to the noninvasive generation of controlled RA concentration patterns in vivo.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200800037