Anti-HIV coumarins from calophyllum seed oil

The seeds of Calophyllum cerasiferum Vesque (Family - Clusiaceae), and Calophyllum inophyllum Linn. (Family - Clusiaceae) contain several known coumarins, among which were the potent HIV reverse transcriptase inhibitors costatolide and inophyllum P. Calophyllum cerasiferum contained (−)-calanolide B as its major coumarin constituent in significant amount and thus constitute a renewable source of this compound. Costatolide, soullatrolide, and other pyranocoumarins were isolated from the seeds of two Calophyllum species.