Controversies of total mesorectal excision for rectal cancer in elderly patients

Summary The cornerstone of treatment for rectal cancer is resectional treatment according to the principles of total mesorectal excision (TME). However, population-based registries show that improvements in outcome after resectional treatment occur mainly in younger patients. Furthermore, 6-month po...

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Veröffentlicht in:	The lancet oncology 2008-05, Vol.9 (5), p.494-501
Hauptverfasser:	Rutten, Harm JT, Dr, den Dulk, Marcel, MD, Lemmens, Valery EPP, PhD, van de Velde, Cornelis JH, Prof, Marijnen, Corrie AM, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Distribution Age Factors Age groups Aged Aged, 80 and over Aging Anastomosis, Surgical - adverse effects Cancer therapies Colorectal cancer Comorbidity Datasets Digestive System Surgical Procedures - adverse effects Health Services for the Aged Hematology, Oncology and Palliative Medicine Humans Medical prognosis Middle Aged Mortality Neoadjuvant Therapy Netherlands - epidemiology Older people Patient Selection Patients Population-based studies Radiation therapy Radiotherapy, Adjuvant Rectal Neoplasms - mortality Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectum - radiation effects Rectum - surgery Risk Assessment Software Surgery Survival Analysis Treatment Outcome
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Zusammenfassung:	Summary The cornerstone of treatment for rectal cancer is resectional treatment according to the principles of total mesorectal excision (TME). However, population-based registries show that improvements in outcome after resectional treatment occur mainly in younger patients. Furthermore, 6-month postoperative mortality is significantly increased in elderly patients (≥75 years of age) compared with younger patients (
ISSN:	1470-2045 1474-5488
DOI:	10.1016/S1470-2045(08)70129-3