Allogeneic Peripheral Blood Stem Cell Transplantation for the Treatment of Refractory Follicular Lymphoma

Allogeneic Peripheral Blood Stem Cell Transplantation for the Treatment of Refractory Follicular Lymphoma

A 38-year-old male with follicular lymphoma at clinical stage IV failed to achieve complete remission (CR), and developed leukemic change. After the patient was further treated with intensive chemotherapy for acute lymphoblastic leukemia, lymphoma cells in the peripheral blood and bone marrow disapp...

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Veröffentlicht in:Internal Medicine 1998, Vol.37(12), pp.1050-1054
Hauptverfasser: MASUDA, Ritsuko, TESHIMA, Takanori, ISHIMARU, Fumihiko, SHINAGAWA, Katsuji, NAKAYAMA, Hiroyuki, SHIMONO, Michihide, ASAKURA, Shoji, OHMOTO, Eijiro, HARADA, Mine
Format: Artikel
Sprache:eng
Schlagworte:
Adult
allotransplantation
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
DNA Primers - chemistry
DNA, Neoplasm - analysis
Follow-Up Studies
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation
high-dose chemotherapy
Histocompatibility Testing
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocyte Count
Lymphoma, Follicular - immunology
Lymphoma, Follicular - pathology
Lymphoma, Follicular - therapy
Male
Medical sciences
peripheral blood stem cell (PBSC)
Polymerase Chain Reaction
T-Lymphocytes - immunology
Transplantation, Homologous
Whole-Body Irradiation
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Beschreibung
Zusammenfassung:A 38-year-old male with follicular lymphoma at clinical stage IV failed to achieve complete remission (CR), and developed leukemic change. After the patient was further treated with intensive chemotherapy for acute lymphoblastic leukemia, lymphoma cells in the peripheral blood and bone marrow disappeared, but the bulky mass persisted. Then, the patient received allogeneic peripheral blood stem cell transplantation (allo-PBSCT) from his human lymphocyte antigen (HLA)-identical brother following high-dose cyclophosphamide and 12Gy total body irradiation, and the patient achieved CR with the disappearance of Bcl-2 rearrangement. The patient is now alive in continuous CR for more than 19 months after allo-PBSCT. (Internal Medicine 37: 1050-1054, 1998)
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.37.1050