A Comparison of Electrophysiologic Properties between Responders and Non-responders to DL-sotalol among Patients with Ventricular Tachyarrhythmia: Importance of the Lack of a Reverse Use-dependent Effect on Ventricular Refractoriness to Responders

A Comparison of Electrophysiologic Properties between Responders and Non-responders to DL-sotalol among Patients with Ventricular Tachyarrhythmia: Importance of the Lack of a Reverse Use-dependent Effect on Ventricular Refractoriness to Responders

This study was undertaken to determine whether dl-sotalol can prevent ventricular tachyarrhythmia inducibility that can be predicted from electrophysiologic parameters. The effects of dl-sotalol in 16 patients (ventricular tachycardia (VT) in 11 and fibrillation (VF) in 5) were determined in electro...

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Veröffentlicht in:Japanese Heart Journal 1998, Vol.39(5), pp.619-630
Hauptverfasser: NAITOH, Naoki, YAMAURA, Masayuki, TAGAWA, Minoru, AIZAWA, Yoshifusa
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials - drug effects
Adrenergic beta-Agonists - administration & dosage
Adult
Aged
Anti-Arrhythmia Agents - therapeutic use
Antiarythmic agents
Biological and medical sciences
Cardiovascular system
Dl-sotalol
Electrocardiography
Electrophysiology
Female
Humans
Isoproterenol - administration & dosage
Male
Medical sciences
Middle Aged
Non-responders
Pharmacology. Drug treatments
Potassium Channels - drug effects
Refractory period
Refractory Period, Electrophysiological
Responders
Sotalol - therapeutic use
Tachycardia, Ventricular - drug therapy
Tachycardia, Ventricular - physiopathology
Use dependent effect
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Zusammenfassung:This study was undertaken to determine whether dl-sotalol can prevent ventricular tachyarrhythmia inducibility that can be predicted from electrophysiologic parameters. The effects of dl-sotalol in 16 patients (ventricular tachycardia (VT) in 11 and fibrillation (VF) in 5) were determined in electrophysiologic studies before and after dl-sotalol (320mg/day). In 9 of 16 patients (56%) after dl-sotalol, ventricular tachyarrhythmia could not be induced by the entire stimulation protocol (responders). There were significant differences in QT interval (462±52 vs. 415±34 msec; p
ISSN:0021-4868
1348-673X
DOI:10.1536/ihj.39.619