EARLY PATTERNING OF THE C. ELEGANS EMBRYO

Studies of about 20 maternally expressed genes are providing an understanding of mechanisms of patterning and cell-fate determination in the early Caenorhabditis elegans embryo. The analyses have revealed that fates of the early blastomeres are specified by a combination of intrinsically asymmetric...

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Veröffentlicht in:	Annual review of genetics 1998-01, Vol.32 (1), p.521-545
Hauptverfasser:	Rose, Lesilee S, Kemphues, Kenneth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals asymmetric division Biological and medical sciences Body Patterning - genetics Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Cell Communication Cell Division cell-cell signaling Cellular biology Classical genetics, quantitative genetics, hybrids Embryos Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Gene mutations Genes, Helminth Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Invertebrata maternal-effect mutation Mutation Nematoda Signal Transduction spindle orientation
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Beschreibung
Zusammenfassung:	Studies of about 20 maternally expressed genes are providing an understanding of mechanisms of patterning and cell-fate determination in the early Caenorhabditis elegans embryo. The analyses have revealed that fates of the early blastomeres are specified by a combination of intrinsically asymmetric cell divisions and two types of cell-cell interactions: inductions and polarizing interactions. In this review we summarize the current level of understanding of the molecular mechanisms underlying these processes in the specification of cell fates in the pregastrulation embryo.
ISSN:	0066-4197 1545-2948
DOI:	10.1146/annurev.genet.32.1.521