Diabetes Increases Atrophy and Vascular Lesions on Brain MRI in Patients With Symptomatic Arterial Disease

Diabetes type 2 (DM2) is associated with accelerated cognitive decline and structural brain abnormalities. Macrovascular disease has been described as a determinant for brain MRI changes in DM2, but little is known about the involvement of other DM2-related factors. Brain MRI was performed in 1043 p...

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Veröffentlicht in:	Stroke (1970) 2008-05, Vol.39 (5), p.1600-1603
Hauptverfasser:	TIEHUIS, Audrey M, VAN DER GRAAF, Yolanda, VISSEREN, Frank L, VINCKEN, Koen L, BIESSELS, Geert Jan, APPELMAN, Auke P. A, KAPPELLE, L. Jaap, MALI, Willem P. T. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atrophy - etiology Atrophy - pathology Atrophy - physiopathology Biological and medical sciences Brain - blood supply Brain - pathology Brain - physiopathology Cerebral Arteries - pathology Cerebral Arteries - physiopathology Cerebrovascular Disorders - etiology Cerebrovascular Disorders - pathology Cerebrovascular Disorders - physiopathology Cognition Disorders - etiology Cognition Disorders - pathology Cognition Disorders - physiopathology Cohort Studies Dementia - etiology Dementia - pathology Dementia - physiopathology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - physiopathology Disease Progression Female Humans Hyperglycemia - complications Hyperglycemia - physiopathology Intracranial Arteriosclerosis - complications Intracranial Arteriosclerosis - pathology Intracranial Arteriosclerosis - physiopathology Investigative techniques, diagnostic techniques (general aspects) Leukoaraiosis - etiology Leukoaraiosis - pathology Leukoaraiosis - physiopathology Magnetic Resonance Imaging Male Medical sciences Middle Aged Nervous system Neurology Predictive Value of Tests Prospective Studies Risk Factors Ultrasonic investigative techniques Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	Diabetes type 2 (DM2) is associated with accelerated cognitive decline and structural brain abnormalities. Macrovascular disease has been described as a determinant for brain MRI changes in DM2, but little is known about the involvement of other DM2-related factors. Brain MRI was performed in 1043 participants (151 DM2) with symptomatic arterial disease. Brain volumes were obtained through automated segmentation. Patients with arterial disease and DM2 had more global and subcortical brain atrophy (-1.20% brain/intracranial volume [95%CI -1.58 to -0.82], P
ISSN:	0039-2499 1524-4628
DOI:	10.1161/STROKEAHA.107.506089