Anti-tumor effect of β-elemene in glioblastoma cells depends on p38 MAPK activation

Abstract β- Elemene, a natural plant drug extracted from Curcuma wenyujin, has been used as an antitumor drug for different tumors, including glioblastoma. However, the mechanism of its anti-tumor effect is largely unknown. Here we report that anti-proliferation of glioblastoma cells induced by β-elemene was dependent on p38 MAPK activation. Treatment of glioblastoma cell lines with β - elemene, led to phosphorylation of p38 MAPK, cell-cycle arrest in G0/G1 phase and inhibition of proliferation of these cells. Inhibition of p38 MAPK reversed β - elemene-mediated anti-proliferation effect. Furthermore, the growth of glioblastoma cell-transplanted tumors in nude mice was inhibited by intraperitoneal injection of β-elemene. Taken together, our findings indicate that activation of p38 MAPK is critical for the anti-proliferation effect of β-elemene and that p38 MAPK might be a putative pharmacological target for glioblastoma therapy.