Long-QT Syndrome After Age 40

Long-QT Syndrome After Age 40

Previous studies that assessed the risk of life-threatening cardiac events in patients with congenital long-QT syndrome (LQTS) have focused mainly on the first 4 decades of life, whereas the clinical course of this inherited cardiac disorder in the older population has not been studied. The risk of...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2008-04, Vol.117 (17), p.2192-2201
Hauptverfasser: GOLDENBERG, Ilan, MOSS, Arthur J, BENHORIN, Jesaia, KAUFMAN, Elizabeth S, LOCATI, Emanuela H, NAPOLITANO, Carlo, PRIORI, Silvia G, MING QI, SCHWARTZ, Peter J, TOWBIN, Jeffrey A, VINCENT, G. Michael, LI ZHANG, BRADLEY, James, POLONSKY, Slava, PETERSON, Derick R, MCNITT, Scott, ZAREBA, Wojciech, ANDREWS, Mark L, ROBINSON, Jennifer L, ACKERMAN, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Adrenergic beta-Antagonists - therapeutic use
Adult
Age Distribution
Aged
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Death, Sudden, Cardiac - epidemiology
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Electrocardiography
Female
Genotype
Humans
Kaplan-Meier Estimate
Long QT Syndrome - diagnostic imaging
Long QT Syndrome - drug therapy
Long QT Syndrome - genetics
Long QT Syndrome - mortality
Male
Medical sciences
Middle Aged
Multivariate Analysis
Pacemaker, Artificial
Phenotype
Registries
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Ultrasonography
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Zusammenfassung:Previous studies that assessed the risk of life-threatening cardiac events in patients with congenital long-QT syndrome (LQTS) have focused mainly on the first 4 decades of life, whereas the clinical course of this inherited cardiac disorder in the older population has not been studied. The risk of aborted cardiac arrest or death from age 41 though 75 years was assessed in 2759 subjects from the International LQTS Registry, categorized into electrocardiographically affected (corrected QT interval [QTc] > or = 470 ms), borderline (QTc 440 to 469 ms), and unaffected (QTc < 440 ms) subgroups. The affected versus unaffected adjusted hazard ratio for aborted cardiac arrest or death was 2.65 (P
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.107.729368