The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x)
The design and synthesis of a series of analogues of sialyl Lewis(x)(1) which incorporate conformationally rigid tetralin and naphthalene ring systems(2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion.
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 1998-12, Vol.6 (12), p.2421-2439 |
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| container_end_page | 2439 |
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| container_issue | 12 |
| container_start_page | 2421 |
| container_title | Bioorganic & medicinal chemistry |
| container_volume | 6 |
| creator | Murphy, P V Hubbard, R E Manallack, D T Wills, R E Montana, J G Taylor, R J |
| description | The design and synthesis of a series of analogues of sialyl Lewis(x)(1) which incorporate conformationally rigid tetralin and naphthalene ring systems(2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion. |
| doi_str_mv | 10.1016/S0968-0896(98)80017-5 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 1998-12, Vol.6 (12), p.2421-2439 |
| issn | 0968-0896 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69151095 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Carbohydrate Conformation Carbohydrate Sequence Cell Adhesion - drug effects Cell Adhesion - physiology Cells, Cultured Computer Graphics Drug Design Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Fucose HL-60 Cells Humans Indicators and Reagents Models, Molecular Molecular Sequence Data Molecular Structure Naphthalenes Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - pharmacology Structure-Activity Relationship Tetrahydronaphthalenes Tumor Necrosis Factor-alpha - pharmacology Umbilical Veins |
| title | The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x) |
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