The design, synthesis, and evaluation of novel conformationally rigid analogues of sialyl Lewis(x)

The design and synthesis of a series of analogues of sialyl Lewis(x)(1) which incorporate conformationally rigid tetralin and naphthalene ring systems(2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 1998-12, Vol.6 (12), p.2421-2439
Hauptverfasser:	Murphy, P V, Hubbard, R E, Manallack, D T, Wills, R E, Montana, J G, Taylor, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrate Conformation Carbohydrate Sequence Cell Adhesion - drug effects Cell Adhesion - physiology Cells, Cultured Computer Graphics Drug Design Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Fucose HL-60 Cells Humans Indicators and Reagents Models, Molecular Molecular Sequence Data Molecular Structure Naphthalenes Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - pharmacology Structure-Activity Relationship Tetrahydronaphthalenes Tumor Necrosis Factor-alpha - pharmacology Umbilical Veins
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Beschreibung
Zusammenfassung:	The design and synthesis of a series of analogues of sialyl Lewis(x)(1) which incorporate conformationally rigid tetralin and naphthalene ring systems(2-4) has led to novel compounds which have similar potency to 1 as inhibitors of cell adhesion.
ISSN:	0968-0896
DOI:	10.1016/S0968-0896(98)80017-5