Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)
The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not mac...
Gespeichert in:
| Veröffentlicht in: | Biomedicine & pharmacotherapy 1998-01, Vol.52 (10), p.436-439 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 439 |
|---|---|
| container_issue | 10 |
| container_start_page | 436 |
| container_title | Biomedicine & pharmacotherapy |
| container_volume | 52 |
| creator | Lachgar, A Jaureguiberry, G Le Buenac, H Bizzini, B Zagury, JF Rappaport, J Zagury, D |
| description | The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not macrophage inflammatory protein 1α (MIP-1α) or MIP-1β. DARC has also been identified to a receptor for malaria parasites
Plasmodium vivax and
Plasmodium knowlesi. In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to peripheral blood mononuclear cells (PBMCs). Furthermore, binding of HIV-1 particles to RBCs is inhibited by treating these cells with recombinant RANTES, but not with recombinant MIP-1α prior to their incubation with HIV-1. This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells. |
| doi_str_mv | 10.1016/S0753-3322(99)80021-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69150888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0753332299800213</els_id><sourcerecordid>69150888</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-a6a4d33d8b765cc0e65f5ddc1afb0ef1d6e366be32ba564efc9d748f72a520293</originalsourceid><addsrcrecordid>eNqFkE1rGzEQhkVocVwnPyGgU4kP244kS7s6FWfdNoFAwfm4il1plCi1V460NuTfdx2bXHsahveZGeYh5ILBNwZMfb-DUopCCM4vtZ5WAJwV4oSMmZZQKIDyExl_IKfkS84vACCVqEZkpDVnM8bH5O4qdC50TzR6en3zWDDaR7q8qjMN3S6udphp_4x0sfX-jc67PjxhR5docdPHlKmPidbPuI5_Qzegl4v5sp6ekc--WWU8P9YJefj1876-Lm7__L6p57eFFQr6olHNzAnhqrZU0lpAJb10zrLGt4CeOYVCqRYFbxupZuitduWs8iVvJAeuxYR8PezdpPi6xdybdcgWV6umw7jNRmkmoaqqAZQH0KaYc0JvNimsm_RmGJi9TPMu0-xNGa3Nu8yhm5CL44Ftu0b3MXW0N-Q_DjkOX-4CJpNtwM6iCwltb1wM_7nwD9YMglQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69150888</pqid></control><display><type>article</type><title>Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Lachgar, A ; Jaureguiberry, G ; Le Buenac, H ; Bizzini, B ; Zagury, JF ; Rappaport, J ; Zagury, D</creator><creatorcontrib>Lachgar, A ; Jaureguiberry, G ; Le Buenac, H ; Bizzini, B ; Zagury, JF ; Rappaport, J ; Zagury, D</creatorcontrib><description>The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not macrophage inflammatory protein 1α (MIP-1α) or MIP-1β. DARC has also been identified to a receptor for malaria parasites
Plasmodium vivax and
Plasmodium knowlesi. In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to peripheral blood mononuclear cells (PBMCs). Furthermore, binding of HIV-1 particles to RBCs is inhibited by treating these cells with recombinant RANTES, but not with recombinant MIP-1α prior to their incubation with HIV-1. This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/S0753-3322(99)80021-3</identifier><identifier>PMID: 9921412</identifier><language>eng</language><publisher>France: Elsevier SAS</publisher><subject>AIDS/HIV ; Antigens, Protozoan ; Carrier Proteins - immunology ; Carrier Proteins - metabolism ; chemokines ; Chemokines - blood ; DARC ; Duffy ; Duffy Blood-Group System ; Enzyme-Linked Immunosorbent Assay ; Erythrocytes - immunology ; Erythrocytes - virology ; HIV-1 ; HIV-1 - metabolism ; Humans ; In Vitro Techniques ; Protozoan Proteins ; RANTES ; RBC ; Receptors, Antigen - blood ; Receptors, Cell Surface - immunology ; Receptors, Cell Surface - metabolism</subject><ispartof>Biomedicine & pharmacotherapy, 1998-01, Vol.52 (10), p.436-439</ispartof><rights>1998 Elsevier, Paris</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-a6a4d33d8b765cc0e65f5ddc1afb0ef1d6e366be32ba564efc9d748f72a520293</citedby><cites>FETCH-LOGICAL-c360t-a6a4d33d8b765cc0e65f5ddc1afb0ef1d6e366be32ba564efc9d748f72a520293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0753-3322(99)80021-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9921412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lachgar, A</creatorcontrib><creatorcontrib>Jaureguiberry, G</creatorcontrib><creatorcontrib>Le Buenac, H</creatorcontrib><creatorcontrib>Bizzini, B</creatorcontrib><creatorcontrib>Zagury, JF</creatorcontrib><creatorcontrib>Rappaport, J</creatorcontrib><creatorcontrib>Zagury, D</creatorcontrib><title>Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not macrophage inflammatory protein 1α (MIP-1α) or MIP-1β. DARC has also been identified to a receptor for malaria parasites
Plasmodium vivax and
Plasmodium knowlesi. In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to peripheral blood mononuclear cells (PBMCs). Furthermore, binding of HIV-1 particles to RBCs is inhibited by treating these cells with recombinant RANTES, but not with recombinant MIP-1α prior to their incubation with HIV-1. This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells.</description><subject>AIDS/HIV</subject><subject>Antigens, Protozoan</subject><subject>Carrier Proteins - immunology</subject><subject>Carrier Proteins - metabolism</subject><subject>chemokines</subject><subject>Chemokines - blood</subject><subject>DARC</subject><subject>Duffy</subject><subject>Duffy Blood-Group System</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Erythrocytes - immunology</subject><subject>Erythrocytes - virology</subject><subject>HIV-1</subject><subject>HIV-1 - metabolism</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Protozoan Proteins</subject><subject>RANTES</subject><subject>RBC</subject><subject>Receptors, Antigen - blood</subject><subject>Receptors, Cell Surface - immunology</subject><subject>Receptors, Cell Surface - metabolism</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVocVwnPyGgU4kP244kS7s6FWfdNoFAwfm4il1plCi1V460NuTfdx2bXHsahveZGeYh5ILBNwZMfb-DUopCCM4vtZ5WAJwV4oSMmZZQKIDyExl_IKfkS84vACCVqEZkpDVnM8bH5O4qdC50TzR6en3zWDDaR7q8qjMN3S6udphp_4x0sfX-jc67PjxhR5docdPHlKmPidbPuI5_Qzegl4v5sp6ekc--WWU8P9YJefj1876-Lm7__L6p57eFFQr6olHNzAnhqrZU0lpAJb10zrLGt4CeOYVCqRYFbxupZuitduWs8iVvJAeuxYR8PezdpPi6xdybdcgWV6umw7jNRmkmoaqqAZQH0KaYc0JvNimsm_RmGJi9TPMu0-xNGa3Nu8yhm5CL44Ftu0b3MXW0N-Q_DjkOX-4CJpNtwM6iCwltb1wM_7nwD9YMglQ</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Lachgar, A</creator><creator>Jaureguiberry, G</creator><creator>Le Buenac, H</creator><creator>Bizzini, B</creator><creator>Zagury, JF</creator><creator>Rappaport, J</creator><creator>Zagury, D</creator><general>Elsevier SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)</title><author>Lachgar, A ; Jaureguiberry, G ; Le Buenac, H ; Bizzini, B ; Zagury, JF ; Rappaport, J ; Zagury, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-a6a4d33d8b765cc0e65f5ddc1afb0ef1d6e366be32ba564efc9d748f72a520293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS/HIV</topic><topic>Antigens, Protozoan</topic><topic>Carrier Proteins - immunology</topic><topic>Carrier Proteins - metabolism</topic><topic>chemokines</topic><topic>Chemokines - blood</topic><topic>DARC</topic><topic>Duffy</topic><topic>Duffy Blood-Group System</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Erythrocytes - immunology</topic><topic>Erythrocytes - virology</topic><topic>HIV-1</topic><topic>HIV-1 - metabolism</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Protozoan Proteins</topic><topic>RANTES</topic><topic>RBC</topic><topic>Receptors, Antigen - blood</topic><topic>Receptors, Cell Surface - immunology</topic><topic>Receptors, Cell Surface - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lachgar, A</creatorcontrib><creatorcontrib>Jaureguiberry, G</creatorcontrib><creatorcontrib>Le Buenac, H</creatorcontrib><creatorcontrib>Bizzini, B</creatorcontrib><creatorcontrib>Zagury, JF</creatorcontrib><creatorcontrib>Rappaport, J</creatorcontrib><creatorcontrib>Zagury, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lachgar, A</au><au>Jaureguiberry, G</au><au>Le Buenac, H</au><au>Bizzini, B</au><au>Zagury, JF</au><au>Rappaport, J</au><au>Zagury, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>52</volume><issue>10</issue><spage>436</spage><epage>439</epage><pages>436-439</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not macrophage inflammatory protein 1α (MIP-1α) or MIP-1β. DARC has also been identified to a receptor for malaria parasites
Plasmodium vivax and
Plasmodium knowlesi. In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to peripheral blood mononuclear cells (PBMCs). Furthermore, binding of HIV-1 particles to RBCs is inhibited by treating these cells with recombinant RANTES, but not with recombinant MIP-1α prior to their incubation with HIV-1. This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells.</abstract><cop>France</cop><pub>Elsevier SAS</pub><pmid>9921412</pmid><doi>10.1016/S0753-3322(99)80021-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 1998-01, Vol.52 (10), p.436-439 |
| issn | 0753-3322 1950-6007 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69150888 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | AIDS/HIV Antigens, Protozoan Carrier Proteins - immunology Carrier Proteins - metabolism chemokines Chemokines - blood DARC Duffy Duffy Blood-Group System Enzyme-Linked Immunosorbent Assay Erythrocytes - immunology Erythrocytes - virology HIV-1 HIV-1 - metabolism Humans In Vitro Techniques Protozoan Proteins RANTES RBC Receptors, Antigen - blood Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism |
| title | Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T11%3A02%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Binding%20of%20HIV-1%20to%20RBCs%20involves%20the%20Duffy%20Antigen%20Receptors%20for%20Chemokines%20(DARC)&rft.jtitle=Biomedicine%20&%20pharmacotherapy&rft.au=Lachgar,%20A&rft.date=1998-01-01&rft.volume=52&rft.issue=10&rft.spage=436&rft.epage=439&rft.pages=436-439&rft.issn=0753-3322&rft.eissn=1950-6007&rft_id=info:doi/10.1016/S0753-3322(99)80021-3&rft_dat=%3Cproquest_cross%3E69150888%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69150888&rft_id=info:pmid/9921412&rft_els_id=S0753332299800213&rfr_iscdi=true |