Binding of HIV-1 to RBCs involves the Duffy Antigen Receptors for Chemokines (DARC)
The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not mac...
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Veröffentlicht in: | Biomedicine & pharmacotherapy 1998-01, Vol.52 (10), p.436-439 |
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Sprache: | eng |
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Zusammenfassung: | The Duffy Antigen Receptor for Chemokines (DARC) belongs to a family of erythrocyte chemokine receptors that bind C-X-C and C-C chemokines such as interleukin 8 (IL-8), monocyte chemoattractant protein 1 (MCP-1) and regulated-on-activation, normal T cell-expressed and -secreted (RANTES). but not macrophage inflammatory protein 1α (MIP-1α) or MIP-1β. DARC has also been identified to a receptor for malaria parasites
Plasmodium vivax and
Plasmodium knowlesi. In the present study, we show that HIV-1 binds to RBCs from Caucasian individuals via DARC making RBCs able to transmit HIV to peripheral blood mononuclear cells (PBMCs). Furthermore, binding of HIV-1 particles to RBCs is inhibited by treating these cells with recombinant RANTES, but not with recombinant MIP-1α prior to their incubation with HIV-1. This finding suggests that RBCs may function as a reservoir for HIV-1 or as a receptor for the entry of HIV-1 into CD4-cell subsets as well as neurons or endothelial cells. |
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ISSN: | 0753-3322 1950-6007 |
DOI: | 10.1016/S0753-3322(99)80021-3 |