Significance of the minor i and t determinants of hepatitis B virus in hepatocellular carcinoma

Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gen...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 1998-12, Vol.13 (12), p.1237-1240
Hauptverfasser:	YI ZHAO, OON, C. J, LIM, G. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Carcinoma, Hepatocellular - virology DNA, Viral - blood Epitopes - blood Epitopes - genetics Epitopes - immunology Gastroenterology. Liver. Pancreas. Abdomen Hepatitis B Surface Antigens - blood Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Hepatitis B virus - genetics Hepatitis B virus - immunology Humans Liver Neoplasms - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Middle Aged Polymerase Chain Reaction Tropical medicine Tumors
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Zusammenfassung:	Stored sera from asymptomatic hepatitis B virus (HBV) carriers and hepatitis B virus surface antigen-positive hepatocellular carcinoma (HCC) patients were tested for HBV subtypes, such as subtype determinants d, y, w, r and also antigenic determinants isoleucine (i) and threonine (t) by direct S gene nucleotide sequencing. Significant changes in minor i and t determinants in hepatocellular carcinoma patients with adr hepatitis B carriers were seen. The adr subtype with t determinant was present in 14/25 (56%) of HCC patients compared with only two of 28 (7%) in asymptomatic hepatitis B carriers (P
ISSN:	0815-9319 1440-1746
DOI:	10.1111/j.1440-1746.1998.tb00611.x