Spermatogonial stem cells

The mammalian seminiferous epithelium consists of a highly complex yet well-organized cell population, with germ cells in mitosis and meiosis and postmeiotic cells undergoing transformation to become spermatozoa. To study the factors which control renewal and differentiation of spermatogonial stem c...

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Veröffentlicht in:	Current opinion in cell biology 1998-12, Vol.10 (6), p.694-701
Hauptverfasser:	de Rooij, Dirk G, Grootegoed, J Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Cell Differentiation Cell Division Germ Cells - cytology Humans Male Spermatogenesis Stem Cells - cytology
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The mammalian seminiferous epithelium consists of a highly complex yet well-organized cell population, with germ cells in mitosis and meiosis and postmeiotic cells undergoing transformation to become spermatozoa. To study the factors which control renewal and differentiation of spermatogonial stem cells, animal models are now available which allow for arrest and restart of spermatogonial differentiation. In addition, marked progress has been made in understanding the control of apoptosis and its role in spermatogonia. For the future, spermatogonial stem cell transplantation may have important practical applications.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/S0955-0674(98)80109-9