Glycosides from the Root of Iodes cirrhosa

Seven new neolignan glycosides (1–7), two arylglycerol glycosides (8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of Iodes cirrhosa. Their structures including absolute configurations were determined by spectroscopic and chemical methods. Based on analysis of the NMR data of threo and erythro 8–4′-oxyneolignans and arylglycerols in different solvents, the validity of J 7,8 and ΔδC8−C7 values to distinguish threo and erythro derivatives was discussed. In the in vitro assays, compound 4 and liriodendrin (17) both showed activity against glutamate-induced PC12 cell damage at 10−5 M.