Usimines A−C, Bioactive Usnic Acid Derivatives from the Antarctic Lichen Stereocaulon alpinum

Usimines A−C (1–3), three new usnic acid derivatives, have been isolated from a MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of 1–3 were determined by analysis of their spectroscopic data (NMR, UV, MS) and by chemical methods. The known...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-04, Vol.71 (4), p.710-712
Hauptverfasser:	Seo, Changon, Sohn, Jae Hak, Park, Seong Min, Yim, Joung Han, Lee, Hong Kum, Oh, Hyuncheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Antarctic Regions Benzofurans - chemistry Benzofurans - isolation & purification Benzofurans - pharmacology Biological and medical sciences General pharmacology Humans Lichens - chemistry Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Stereocaulon alpinum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Usimines A−C (1–3), three new usnic acid derivatives, have been isolated from a MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structures of 1–3 were determined by analysis of their spectroscopic data (NMR, UV, MS) and by chemical methods. The known compound usnic acid (4) was also obtained. Compounds 1–4 showed moderate inhibitory activity against therapeutically targeted protein tyrosine phosphatase 1B (PTP1B).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np070464b