Alkyl peroxyl radical-scavenging activity of catechins

Alkyl peroxyl radical-scavenging activity of catechins

Alkyl peroxyl radical (ROO ) generated from the reaction between 20 mM t-butyl hydroperoxide ( t-BuOOH) and 200 μM hematin could kill E. coli. The minimum concentrations of catechins sufficient to rescue the bacteria treated with ROO were found to be 70 μM for (−)-epicatechingallate, 100 μM for (−)-...

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Veröffentlicht in:Phytochemistry (Oxford) 1998-12, Vol.49 (8), p.2379-2382
Hauptverfasser: Nakao, Mayumi, Takio, Susumu, Ono, Kanji
Format: Artikel
Sprache:eng
Schlagworte:
alkyl peroxyl radical
antibacterial properties
antioxidant
ascorbic acid
bactericidal action
beta-carotene
bioassays
Biological and medical sciences
Catechin - analogs & derivatives
Catechin - pharmacology
catechins
dosage
Escherichia coli
Escherichia coli - drug effects
flavonols
Free Radical Scavengers - pharmacology
free radicals
General pharmacology
Heme - chemistry
inhibitors
Medical sciences
oxidation
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
radical scavenger
Reactive Oxygen Species
Staphylococcus aureus - drug effects
superoxide dismutase
tert-Butylhydroperoxide - chemistry
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Zusammenfassung:Alkyl peroxyl radical (ROO ) generated from the reaction between 20 mM t-butyl hydroperoxide ( t-BuOOH) and 200 μM hematin could kill E. coli. The minimum concentrations of catechins sufficient to rescue the bacteria treated with ROO were found to be 70 μM for (−)-epicatechingallate, 100 μM for (−)-epicatechin and 125 μM for (+)-catechin. These values were comparable with the value of α-tocopherol, a typical ROO scavenger. On the other hand, l-ascorbate and β-carotene revealed about one tenth the scavenging activity of catechins. No scavenging activity was found for superoxide dismutase even at 86 mM. These facts indicate that catechins have high ROO scavenging activity.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(98)00333-1