Detection of the t(2;5)‐associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals

The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK on chromosome 2p23, is found in CD30+ anaplastic large cell lymphomas and some cases of B‐cell lymphoma. Hodgkin's disease (HD) is a malignant lymphoma characterized...

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Veröffentlicht in:	British journal of haematology 1998-12, Vol.103 (4), p.1138-1144
Hauptverfasser:	TRÜMPER, L, PFREUNDSCHUH, M, BONIN, F. V, DAUS, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Southern Chromosome aberrations Chromosomes, Human, Pair 2 - genetics Chromosomes, Human, Pair 5 - genetics DNA, Complementary - genetics Hematology Humans Lymphocyte Subsets - chemistry Lymphocytes - chemistry lymphoma Medical genetics Medical sciences NPM/ALK fusion gene PCR Protein-Tyrosine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - genetics Translocation, Genetic - genetics
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Beschreibung
Zusammenfassung:	The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK on chromosome 2p23, is found in CD30+ anaplastic large cell lymphomas and some cases of B‐cell lymphoma. Hodgkin's disease (HD) is a malignant lymphoma characterized by large multinucleated tumour cells, Hodgkin and Reed‐Sternberg (H&RS) cells, surrounded by a dense lymphohistiocytic infiltrate. Our group recently demonstrated NPM/ALK fusion cDNAs by single‐cell RT‐PCR in
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.1998.01097.x